Thymus-like activities of sulphur derivatives on T-cell differentiation
نویسندگان
چکیده
Levamisole and sodium diethyldithiocarbamate can induce in vivo thymocyte differentiation from precursor spleen cells of nu/nu mice and evoke indirect plaque-forming cells in nude mice immunized with sheep red cells. These sulphur drugs induce in thymusless mice the production of a serum factor which transfer in vivo immune enhancement and in vitro thymocyte differentiation. In vivo treatment with sulphur derivative can substitute for an alleged thymice hormone.
منابع مشابه
Brief Definitive Report THYMUS-LIKE ACTIVITIES OF SULPHUR DERIVATIVES ON T-CELL DIFFERENTIATION* BY GERARD RENOUX AND MICHELINE RENOUX
Levamisole (LMS), the levoisomer of 2,3,5,6-tetrahydro-6-phenylimidazo [2, l-b] thiazole hydrochloride, has demonstrated immunoenhancing activities on mouse responsiveness to antigenic stimuli (1-4). This activity depended upon T-cell potentiation as evidenced by increased gra~-versus-host reaction when donors were treated by LMS (5), by accelerated rejection of isogeneic skin grafts (6, 7), or...
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 145 شماره
صفحات -
تاریخ انتشار 1977